The Cleveland Guardians (73-52) and New York Yankees (73-53) meet in the middle game of a three-game series on Wednesday (Prime Video). The first pitch at Yankee Stadium is scheduled for 7:05 pm ET. Break down FanDuel Sportsbook's Guardians vs. Yankees odds and make your best betting predictions and forecasts from MLB experts.
Season series: 2-2 draw
The Guardians won the series opener 9-5 after 12 innings. They won as moderate underdogs (+120) as the over (8) hit easily. Still, the under is 4-2 in their last six games.
Cleveland's nine-point offensive outburst was a bit of a surprise, as they only managed four total runs in a three-game interleague series rout of the Milwaukee Brewers over the weekend.
The good news is that the Yankees gave up five runs, tying the total they lost in their three-game losing streak at Detroit, but New York also allowed nine runs and has allowed seven or more in six of their past 12 games.
Cleveland has had a rollercoaster run recently, winning five straight from July 28-Aug. 2 before losing seven straight from Aug. 3-9. The Guardians then won five straight from Aug. 10-14 before losing their last three straight.
Yankees Guardians predicted starting lineup
LHP Joey Cantillo vs. LHP
Cantillo (0-2, 6.23 ERA) is making his fourth career start and has a 1.62 WHIP, 4.2 BB/9 and 6.2 K/9 in 13 innings.
Last start: Loss, 5 2/3 innings, 3 runs allowed, 5 hits (2 home runs), 3 walks, 2 strikeouts, 4-2 loss to the Minnesota Twins on Friday 2024 road record: 0-1, 6.00 ERA (9 innings, 6 runs allowed), 1.67 WHIP, Opponents Batting Average (OBA) .265, 6 walks, 5 strikeouts in 2 starts Never faced the Yankees
Cortes (6-10, 4.20 ERA) is making his 26th start and has a 1.19 WHIP, 1.9 BB/9 and 8.5 K/9 in 141 1/3 innings.
Last Start: Aug. 13, 4-1 road win vs. Chicago White Sox, 7 innings, 0 runs, 3 hits, 0 walks, 9 strikeouts. 2024 Home Record: 4-5 in 12 starts, 3.05 ERA (73 2/3 innings, 25 runs), 0.96 WHIP, .224 batting average, 10 home runs, 10 walks, 68 strikeouts. Career Record with Guardians: 6 appearances (3 starts), 1-0 with a 3.68 ERA (22 innings, 9 runs), 0.82 WHIP, 9.8/9 strikeouts.
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Guardians vs Yankees odds
Courtesy of FanDuel Sportsbook. For the complete list, visit the USA TODAY Sports Scores and Sports Betting Odds Hub. Lines last updated at 7:56 a.m. ET.
Money Line (ML): Guardians +136 (bet $100 to win $136) | Yankees -162 (bet $162 to win $100) Run Line (RL)/Against the Spread (ATS): Guardians +1.5 (-160) | Yankees -1.5 (+132) Over/Under (O/U): 8.5 (O: -110 | U: -110)
Yankees Guardians picks and predictions
prediction
Yankees 6, Guardians 3
Money Line
The Yankees (-162) are a solid team looking to bounce back on Wednesday night after losing in extra innings in a high-scoring series opener.
Cantillo struggled early, but injuries to the starting rotation forced Cleveland to bring him in on short notice. Manager Steven Vogt and his pitching staff have done just that in mirror matches, but again, leaving it to Cortes and the home team should do well here.
Against run line/spread
If you’re a little less conservative, bet on the Yankees -1.5 (+132) to win by at least two runs, rather than the moneyline, which is a safer bet.
New York is on a three-game losing streak, so they're a pretty big risk here, but five of their last six wins have been by two or more points.
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Over/Under
OVER 8.5 (-110) is the trend, but I would play half a unit max.
The Over scored a total of 14 runs in the series opener to earn the win, which ended the Yankees' Under's winning streak at three games and saw them average just 4.0 points per game in the three-game weekend series in Detroit.
Cleveland has split the over and under in their last four games at 2-2 and a combined total of 3-3-1 in their last seven road contests, so bet lightly with caution.
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