The NFL schedule for Week 1 features several high-profile NFL matchups between playoff teams and division rivals. Of the 16 NFL games in Week 1, four are matchups between playoff teams from the previous season and three are division matchups. This includes the Chargers vs. Raiders in Los Angeles. Both teams are looking for a breakout season to compete with the Chiefs in the AFC West. The Chargers are 3.5-point favorites in the Week 1 NFL odds, but the Raiders, under Antonio Pierce, have won three of their four games to end the season and could be one of the popular NFL upset picks featured in our Week 1 NFL parlay picks.
How should you approach that matchup and what Week 1 NFL lines should you target when putting together your Week 1 NFL predictions? Before making any Week 1 NFL picks or NFL parlays, be sure to check out the NFL predictions and betting advice from SportsLine's proven computer model.
The model has simulated every NFL game 10,000 times and has returned over $7,000 in profits for every $100 spent on top-tier NFL picks since its inception. The model has an astounding 185-129 record on top-tier NFL picks dating back to the 2017 season and heading into Week 1 of the 2024 NFL season. The model has also gone 39-21 on top-tier NFL picks since Week 7 of last season.
The model has ranked in the top 10 on NFLPickWatch for straight-up NFL picks four of the last six years and beat over 94% of CBS Sports Football Pick'em players four times during that time, placing it pretty high on anyone who follows it.
Now, the model has thoroughly researched Week 1 NFL odds and confidently identified the five best NFL bets. If you successfully match this model's selections, you can expect to pay out a massive 25 to 1 payout. You can see this model's Week 1 NFL picks exclusively at SportsLine.
NFL Week 1 Top Picks
After simulating each game 10,000 times, the model projects the Detroit Lions (-3.5) to win at home against the Los Angeles Rams, a rematch of last season's playoffs that Detroit won 24-23 and will advance to their first NFC Championship Game appearance in more than 30 years.
The Lions also have a home rematch coming up in Week 1 on Sunday Night Football, with Dan Campbell's team makeup looking improved after Detroit spent its first two picks in the 2024 NFL Draft to bolster its secondary. Those improvements, along with home-field advantage, are a big reason why our model projects the Lions to win in over 50% of simulations. For more NFL parlay picks, see here.
How to make an NFL Week 1 parlay
The model also jumped on four other NFL matchups where the lines were said to be way off, including the home favorite covering the spread in nearly 70% of simulations. You can see the model's best NFL Week 1 bets and parlays exclusively at SportsLine.
What's the model's top NFL pick for Week 1, and what other NFL matchups should you target for a 25-to-1 payout? Visit SportsLine now to find out the answers by seeing the model's best Week 1 NFL bets, which are 185-to-129 on our top-rated picks.
